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2 min readUpdated 23 September, 2026

A central plant cools glycol, brine or another secondary fluid circulated to room coolers.

In short: this can keep primary refrigerant in a plant area and serve many rooms, but adds pumps, piping and heat-exchange losses.

Fluid concentration, viscosity, flow and pipe insulation require calculation. The architecture does not remove refrigerant safety duties.

How it differs from DX

In a secondary-loop system the primary refrigerant never enters the cold room. A central chiller plant uses the primary refrigerant (commonly ammonia or CO₂) to cool a secondary fluid — glycol, brine, or chilled water — which is then pumped through insulated pipes to heat exchangers inside each cold room.

The evaporator in the room handles only the benign secondary fluid; the hazardous or high-GWP charge stays contained in one plant room.

Two-loop schematic — a plant room with a small chiller keeps the refrigerant in one place, and a glycol loop runs from the chiller through two cold rooms connected in series and back; the hazardous refrigerant never enters the rooms.
Secondary (indirect) refrigerant system

Pros and cons

Secondary-loop systems
ProsRefrigerant charge concentrated and minimised in one location → smaller leak exposure; major safety win with toxic ammonia or high-pressure CO₂; one fluid loop serves many rooms and setpoints (scalable); the plant can be isolated and serviced without disturbing cold-room operation.
ConsHigh initial cost (central plant + distribution pipework + pumps); an extra heat-exchange step adds a thermodynamic penalty unless carefully designed; pumping power is a parasitic load; multi-zone temperature coordination needs more sophisticated controls.

Typical application

A large meat-processing plant runs ammonia in a central engine room to chill glycol, which is pumped to each processing line and CAM-LOCK store. This keeps ammonia out of public and production areas — satisfying the machinery-room, ventilation, and leak-detection requirements that apply to larger ammonia charges (per EN 378 / ISO 5149) — while serving very high cooling loads across many rooms.

Note that ammonia (R-717) is classed B2L: toxic and mildly flammable. The secondary loop is precisely the architecture that keeps it out of occupied space.

Planning a multi-room facility? Contact [email protected].

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